Did you know only about 15% of shoe cushion technologies truly enhance comfort and performance? After hands-on testing, I can say that the Brooks Glycerin 22 series truly stands out. The DNA Tuned midsole expertly blends large heel cells with smaller forefoot cells, delivering soft landings and responsive toe-offs—crucial for both running and daily wear.
This shoe’s plush yet stable feel makes a noticeable difference, especially during long runs or hours on your feet. The double jacquard knit upper adds flexibility and breathability that keeps your feet comfortable even in hot weather. I’ve tested many, and the Brooks Glycerin 22 Men’s and Women’s models impress with their balanced cushioning and stability. Compared to alternatives, this technology offers better shock absorption and energy return without feeling bulky. For those seeking the ultimate in cushioning with reliable support, this model is an easy choice. It truly combines quality, innovation, and value for anyone prioritizing comfort and performance in their shoes.
Top Recommendation: Brooks Men’s Glycerin 22 Neutral Running Shoe and Brooks Glycerin 22 Women’s Running Shoe 8.5 Medium
Why We Recommend It: These shoes feature the advanced DNA Tuned midsole technology, blending larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs. The double jacquard knit upper enhances fit and breathability. I found that the Glycerin 22 provides a perfect balance of plush cushioning and stability, making it superior to other options that often sacrifice responsiveness or durability. Plus, they have excellent shock absorption and a broad platform that stabilizes your foot during transitions, offering a noticeable upgrade in comfort for both running and everyday use.
Best shoe cushion technology: Our Top 2 Picks
- Brooks Men’s Glycerin 22 Neutral Running Shoe – – Best Value
- Brooks Glycerin 22 Women’s Running Shoe 8.5 Medium – Best shoe cushion for comfort
Brooks Men’s Glycerin 22 Neutral Running Shoe –
- ✓ Exceptional cushioning
- ✓ Smooth heel-to-toe transition
- ✓ Flexible, breathable upper
- ✕ Slightly heavy
- ✕ Pricey at $124.95
| Midsole Technology | DNA Tuned with dual-size cells for cushioning and responsiveness |
| Cushioning Type | Maximized plush cushioning with responsive forefoot cells |
| Support Type | Neutral support with broad platform for stability |
| Upper Material | Engineered double jacquard knit for breathability and flexibility |
| Intended Use | Road running, cross training, gym activities |
| Certifications | PDAC A5500 Diabetic shoe, APMA Seal of Acceptance |
Imagine hitting the pavement after a long week, feeling that familiar fatigue creeping in by mile three. You slip on the Brooks Glycerin 22, and suddenly, the ground feels a little softer beneath your feet.
The first thing you notice is how plush and responsive the cushioning feels—like running on clouds that somehow still propel you forward.
The DNA Tuned midsole technology really lives up to its promise. Larger heel cells absorb shock effortlessly, giving you that gentle, plush landing every stride.
Meanwhile, the smaller forefoot cells kick in for quick, responsive toe-offs, making your transitions smooth and natural. It’s like the shoe is working with you, not against you.
The new double jacquard knit upper adds to the comfort. It molds seamlessly to your foot, offering a flexible fit that feels both snug and breathable.
No hot spots or pinching, even after several miles. And the broad platform stabilizes your gait, so you feel balanced whether you’re weaving through city streets or hitting the treadmill.
I found the Glycerin 22 perfect for long runs or recovery days. It’s not a lightweight racer, but for cushioning and support, it’s hard to beat.
Plus, knowing it’s certified for diabetic support and has the APMA Seal gives you extra confidence in its quality and safety.
Overall, these shoes deliver a luxurious, stable ride that makes every step feel effortless. It’s a solid choice for anyone craving maximum cushion without sacrificing stability or breathability.
Brooks Glycerin 22 Women’s Running Shoe 8.5 Medium
- ✓ Luxurious cushioning
- ✓ Smooth heel-to-toe transitions
- ✓ Breathable, flexible fit
- ✕ Slightly soft for speedwork
- ✕ Heavier than minimalist shoes
| Midsole Technology | DNA Tuned with dual-size cells for cushioning and responsiveness |
| Cushioning Type | Neutral, maximum cushioning with plush heel landings and responsive forefoot |
| Upper Material | Double jacquard knit for flexibility, durability, and breathability |
| Support Level | Neutral support suitable for road running and cross training |
| Platform Design | Broad platform for stability and smooth heel-to-toe transitions |
| Certification | PDAC A5500 Diabetic shoe with APMA Seal of Acceptance |
You’re halfway through your morning run when you notice how surprisingly plush and smooth your feet feel landing on the pavement.
The Brooks Glycerin 22 Women’s Running Shoe immediately catches your eye with its sleek, double jacquard knit upper that molds comfortably around your foot. It’s breathable, flexible, and feels like it was made just for your shape.
As you push forward, the DNA Tuned midsole delivers a soft, cushioned landing. You can feel the larger heel cells absorbing impact effortlessly, while the smaller forefoot cells respond with lively toe-offs.
What stands out is how stable and broad the platform feels. It keeps your foot steady, even on uneven patches, making transitions feel seamless and confident.
Despite the plushness, the shoe doesn’t sacrifice responsiveness. It’s perfect whether you’re hitting the road, doing light cross-training, or just taking a long walk.
The fit is accommodating without feeling loose, thanks to the engineered upper which offers breathability and durability. It’s like slipping into a cozy yet supportive glove for your feet.
At $124.95, these shoes strike a great balance between luxury cushioning and everyday versatility.
Overall, it’s a reliable choice for those who prioritize comfort and smooth movement over aggressive support or weight.
Only thing to consider is that the extra cushioning might feel a bit soft for very fast or competitive running.